Sorry, to be clear, I am running 26x4.9 tires. But, I see what you mean about the extra force applied through the chain from the smaller ring could cause a bit of extra wear!
In any case, the 46t ring actually really does get me where I'd like. At ~2500w with my factory 11-36 cassette, its highest cadence at max power output would still only be about 100rpm or so, which is pretty reasonable
However, my bike has a pretty intrusive chainstay, which means in order to fit anything beyond maybe a 36t chainring, I would actually have to space the ring further out from centerline than the 75mm it already is (120mm BB). By my measurements, a 46t ring would require roughly 10-12mm greater spacing (85-87mm offset. To avoid extreme "cross-chaining," I'd have to lock out the 3 inner cogs, giving me a 1x7 drivetrain.
Now, while I don't love the idea of neutering my 1x drivetrain, it is certainly not the end of the world. Really, if my only options are a 1x10 that becomes a moped after 25mph, or a 1x7 with reasonable cadences at all speeds, I'll take the latter. I would customize the cassette to get the range I need, especially knowing I'll have extra power helping me through the larger cadence changes. Id have to buy the three largest cogs, but something like an 11, 13, 17, 25, 32, 40, 49 would be a pretty sweet range for a 1x7, and get me close to my factory bottom ratio.