I'm out east in NJ. We don't have those things called Goat Heads but we have more than our fair share of thorns and other sharp objects ready to puncture your tires at any moment. I have two fatbikes, a Specialized Fatboy and a Haibike Full FatSix ebike. With both bikes, I initially went with and ran for years, the Mr Tuffy liners and though they worked fairly ok with my 4.6 and 4.0 tires on these fatbikes, I still got flats. This late summer, after really getting tired of flattening out on the roads and trails, I scrapped the idea of tire tubes and liners and went with the tubeless setup that everyone on the fatbike forums said I should have been doing in the first place!
DragN: I would strongly suggest looking over the Schwalbe catalog for a tubeless ready tire in the size you need. From there, I would then look over and familiarize myself with the various tire guards they have on hand for your size tire & see if it also tubeless compatible. In that same vein, a note to Rad Power to see if their rims for your bike can be converted tubeless. If everything points well for going tubeless, I would go for that route first. Trust me, Mr Tuffy's can only do so much. I've had plenty of thorns go through my fatbike tires and Mr Tuffy's only to puncture out and flatten the tube.
If you go tubeless, do understand you will need to still carry a spare tube in case of a big tire slash that no tubeless sealant can handle.
Check with your friendly local bike shop and inquire as to the price of doing the tubeless set up for you. Stans sealant has their fans as well as the Orange Seal brand. My Haibike is a Yamaha mid drive, so changing a rear flat is no different than changing a traditional bike rear flat. Your hub drive is a different beast that requires different steps to remove and reinstall the tire/rim. I'd suggest a few practice runs in the living room, and not on the trail, where it's getting dark, a storm is approaching or the heat is too intense to get comfortable with the steps needed to be done to fix a rear flat or that tire slash that your tubeless set up cannot seal.
Speaking of fixing a tubeless flat, there is a pretty cool system based on larger tubeless car tire flat repair technology:
http://www.dynaplug.com/bike.html I myself have the DynaPlug Mega Pill along with some spare plugs and carry this with me, along with a good air pump, tire irons, spare tube and tire patch kit....just in case. The system is not cheap to buy into, but it buys tremendous peace of mind knowing you've got the bases covered should you flatten out on the trails.
So, to make a long winded post short: 1. Schwalbe tubeless ready tire with some kind of tread guard technology. 2. Go tubeless with a good name brand sealant 3. Carry spare tube, tire pump, tire irons, tubeless tire plugging system at all times along with a good pressure guage. 4. Ask local bike shops if they can convert you over to tubeless 5. Learn how to remove the rear wheel and reinstall in the comfort of home before the poop hits the fan out on the trails!
PS: A catastrophic tubeless flat or tear on the trails means you must use a tube as the tire pressures required to set a tubeless tire bead onto the rim can never be achieved with your hand tire pump. Good luck!
Mike