I'd say a suspension front & rear is worth paying for. Big wheels are much more comfortable over bumps, I'm short so I use 26" but 700 mm is available for tall people. Buy an aluminum frame that fits, not that posts in the air mini.
Hydraulic brakes, not worth it IMHO. Takes special tools to bleed in some cases and one brand takes $30 a pint special brake fluid. I've got mechanical 160 mm disk brakes & I'm fine down 15% grades if a deer jumps out. If I weighed >220 lb I'd opt for 180 mm rotors. (I'm 160 lb) I have to adjust the pad annually to keep the handle pull small enough, takes removing the pannier bag in the rear and a 5 mm wrench. No big deal. After a year and one cable end pulled off, I did upgrade to stainless coated jaguar cables and jaguar brake housing for less drag: from modernbike.com or thebikepartsstore.com
Long trips doesn't require a premium e-bike, it requires a nice regular bike, a motor kit, & two huge batteries and a quick swap setup. You say you're handy, buy some 12 ga wire, some dorman bullet connectors at the auto supply & a 8.3" klein or ideal brand terminal crimp tool. Make some connections. Try to pull them off. (you have to peel back a few strands to fit 12 ga in blue connectors). No, no copper showing out the insulator, you're ready to wire a hub motor kit. Match the wire colors. Make red & black battery connection opposite sex so that you can't install the battery backwards in the dark.
My battery mount is aluminum angle from the home store, connected with 10-24 stainless screws and elastic stop nuts from mcmaster. Mounts to frame on the front basket mount bosses, in the front to balance my loads. Will swap in about 8 minutes with two 7/16" combo wrenches on the 1/4-20 screws. A second battery would fit in the pannier, carried low. 5 mm frame screws & 6 mm mount screws would work too if you have a lot of import stuff.
Voila, you have an 80 mile range bike you paid $3500 for instead of altogether $6000 premium model.
My limit on ride duration is my hips, they get tired of sitting. I already have a wide comfy seat, am exploring options to put a comfy foam cushion on it. Fat melted off my hips instead of my belly, blah.