I have a 2022 Vado SL 5.0 EQ that weighs in at just under 52 lbs fully loaded with fenders and rack, rack bag with assorted contents, 2 full water bottles, 2 range extenders, Garmin Edge Explore 2, and aux blinking headlight and tailight. Plus a 220 lb rider on top. I set my assist ranges to ECO (35-60%), SPORT (55-80%) and TURBO (75-100%). I usually ride at a 14-16 mph pace on long rides using SPORT on level ground and slight uphill, TURBO on significant climbs, and ECO or NO assist on descents or level with tail winds. I have also regeared my bike with a 10-52t Eagle GX1275 cassette using an XD drive freehub and a 46t Wolftooth front ring. This optimizes the assist up to 28 mph in 11th gear, saving 12th gear for descents and the ultra low 52 tooth 1st gear for grinding out climbs.
I recently finished a 171 mile (total of 7,022 ft of elevation), 3 day ride with the ALA "Trek Across Maine". Day 1 was 62 miles (2766 ft elev), Day 2 was 52.3 miles (1421 ft elev), and Day 3 at 56.8 miles (2,835 ft elev). On my ride I ended up using both range extenders each of the three days and ended each day with the bike dipping into its "reduced output" mode when capacity dips below 20%. This equates to a total of around 200% of built-in battery capacity/day with my available battery in the 12-18% at the end of the ride. I had no range anxiety as I knew, based on prior 50 mile+ rides, that I could probably eke out 70 miles by exerting a little more self control and a slower pace.
Generally, I expect that I can get 30 miles at a decent pace with 100% battery capacity, but usually use at least one range extender (total 150%) so that I can make profligate use of TURBO mode on shorter rides.