It all comes down to getting the best bike fit that works for you.
Raising the saddle a full inch is a big change. Does the saddle drop that much when you're just sitting (no road bumps, etc)? How's your leg extension? You want the saddle height to allow nearly full extension at the bottom of the pedal stroke. This gets max power without risking over extension. With the saddle too low not only do you not get max power from each stroke but it can aggravate knee pain. I've noticed that changes of as little as 1/4 inch in saddle height make a noticable difference for me.
Saddle position is next. You want the saddle adjusted front to back to put your knee cap over the center of the pedal when your stroke is horizontal. The ball of your foot should be over the pedal axle though this is a estimate with the standard platform pedals. I use clipless pedals (the ones with the clips, go figure) except when riding in town. They guarantee the correct foot position, allow me to use up-strokes for more power and keep my legs in the cockpit when the bike inevitably goes over. All good things. They are also recommended by my knee doc to help strengthen the muscles around my damaged knee (torn ACL) and my other artificial knee. It works for me. More strength, less pain, better hill climbing, less chance of injury in a fall.
Dropping the saddle angle 2deg might relieve some pressure at the nose. Generally speaking you want the saddle just about level (the Specialized Como saddle is an exception). As long as you don't find yourself gradually sliding forward during the ride a small adjustment from level should be fine. If the angle is too low the tendency to slide forward will increase the pressure on your hands contributing to numbness.
You may want to look at handle bar height. I usually end up raising the bars with a higher angle stem. I haven't found this necessary on my Vado 5. There's a post in the New Vado 5 thread that has specifics on actually changing out the handle bar to get a 50mm rise in position. If you're feeling more than just nominal pressure on your hands you might want to consider this.
Finally, I'd consider upgrading the grips. The same post in the New Vado 5 thread has a pic showing the owner's Vado with Ergon GP3 grips. I use these as well. When properly adjusted they help relieve numbness, esp for those of us with carpel tunnel.
There are a number of videos that go through these and more bike fit techniques. Your LBS probably offers a bike fit service as well. Check 'em out.
