80 miles/130km with a flat bar bike? - Optimistically figure on needing 7whr/km (assuming your in reasonable shape, riding with some care, and being as efficient as you can be). That translates to at least 1200whr of battery (assume you won't/can't drain the battery below 20% due to built in protections). At 48v that's 25amp/hr. So consider having at least that capacity regardless of whether you're looking at a single battery or two. Want to get away with less than 1200w? Train harder so you can input more power over the long period, and practice riding as efficiently as you can (for example using downhills to your advantage, not just to recover). Making it on less than 1000w of battery is possible but it would be more likely on a different bike setup (a lighter and more aero road bike setup)
You're likely going to be in the saddle for 4+ hrs (and more likely 6) so comfort will be important at all the points you touch the bike. This doesn't always mean soft and cushy, the saddle and bars should fit you well (right height, right width, right angles, etc.) and the only way you'll know this is experience in regularly riding beyond about 2 hrs.
Beyond that your into the law of diminishing (but not insignificant) returns. Use efficient tires (with as high a pressure as practical), keep your weight down (try and forgo many of the "extras" many folks regularly ride with), and despite an upright riding position think about your aerodynamics, so ideally no additional bags and such, and no clothing flapping around in the wind.
You're likely going to be in the saddle for 4+ hrs (and more likely 6) so comfort will be important at all the points you touch the bike. This doesn't always mean soft and cushy, the saddle and bars should fit you well (right height, right width, right angles, etc.) and the only way you'll know this is experience in regularly riding beyond about 2 hrs.
Beyond that your into the law of diminishing (but not insignificant) returns. Use efficient tires (with as high a pressure as practical), keep your weight down (try and forgo many of the "extras" many folks regularly ride with), and despite an upright riding position think about your aerodynamics, so ideally no additional bags and such, and no clothing flapping around in the wind.