I'm circling back to complete my story, after getting pretty confident now that I have a few miles on the new spokes. Short story is installing the new spokes (single butted Sapim) seems to have straightened out my issue - which I believe was due to a spoke tension issue as much as anything. When I bought a spoke tension meter to check them, I was told (by Espin) to use the "28" setting on the tension meter for proper tension. This proved inaccurate, as the tension meter I used was calibrated differently. The plan is to tension the spokes to about 100-110 kg. To do that with the meter I purchased, the correct reading on the scale was 35-36, NOT the "28" figure I had been given.
When I retensioned my original spokes to the 28 number, I loosened them badly. My next trip out managed to break 3 spokes within about 5 miles. In hindsight I SHOULD have know something was wrong at that point.
Bottom line, spoke tension is important, and with a heavy butt in play, they're critical. After being through all this, my advice for BigNerd would be to get the spoke tensions checked and set properly. If that doesn't do it, if still breaking spokes, then go with a fresh set of single butted Sapim spokes. Mine were less than 2 bucks cut to the exact length they need to be, purchased through wheelbuilder.com, an outfit I would highly recommend if not buying locally.