No there is more than enough room to use a Knipex on that example bike. The 6" (150mm) version shown by @smorgasbord borders on tiny, and fits within the silhouette of my hand. Looks like about 45 degrees of rotation is possible which is plenty for side-of-the-road use. The 6" is enough to loosen and tighten an axle bolt as thats the one I have been using for that purpose.The problem with Knipex pliers or cone wrenches, or adjustable wrenches is getting them around the nut. (Look at the picture in the original post.) Even if you could get them on the nut there probably won't be enough room to turn them at all.
Knipex wrenches provide an extremely strong grip when the jaws are expanded. Much more than a set of channel locks, plus the jaws always stay parallel so the risk of rounding off a nut is almost zero combined with the kind of grip these things provide. I took this pic awhile back for an article on tools, with a Bafang axle nut in the jaws of the 6" set. That narrow grip you get from expanding the jaws means if your hand is reasonably strong, nothing shifts. You can overtighten a 15mm axle nut to the point it will strip its threads so its fully capable.
I'm sure this ability is why one of them costs fifty bucks, which is enough to create an argument against them right there. But the flaw is cost, not capability.
I have a couple of those from back when I was trying to find a stronger but still rim-friendly tire iron. They bend at the tire iron portion, whose coating also breaks off and exposes bare metal.