What kind of wheetset can we put on the comp E5 to make it lighter- it is 33lbs now? does that make difference? is it worth it?
The first of these three question is fine, the last two are strange... This depends totally on the rider and his/her wallet. Do you really need weight tuning on an already asisted e-bike? And what is a saved gram worth, $1, $2, $10?
For me the Creo is the best e-bike I've ever ridden in terms of that it feels almost like a normal bike. But this is due to it's weight an the tuning of my Comp Evo the last weeks (about two pounds less) even improved that, it feels noticeably better now.
As FlatSix911 said, better&lighter wheels (rims...) have the biggest effect, also on an e-bike. What this is worth to you, it's up to you. Tuning wheels/good carbon wheels are the most expensive part apart from the frame.
The Creo E5 and Comp wheels are heavy AND weak (at least for heavier riders and gravel), so if needed you can improve both facts with new wheels.
The only wheelsets ready to buy with the rare 12x110 front dimensions of the Creo are at the moment the three from DtSwiss already mentioned here:
Frequent chain drop... Hi everyone. I really love my SL Comp Carbon Evo, but both my wife and I (she has an EVO too), frequently experience chain drop when the chain is on the large ring of the rear cassette. It generally happens on steep climbs and it doesn't seem to matter if we are on gravel...
electricbikereview.com
If you stay on roads/only road tires, HEC 1400 Spline 47mm is the best/only choice already build, if you need it for gravel, it's HGC 1400 Spline 42mm with 24mm inner rim width.
If you go to a custom wheel builder you have more options and if you are a light rider also for much lighter wheels/rims than these DT Swiss sets. Prices will be similar.