My Vado 4.0 has the Shimano CS-M7000-11 cassette i.e. 11-speed 11-42 (11-13-15-17-19-21-24-28-32-37-42) and 47-622 tyres.
And it doesn't require quite a spinning in the cogs 17-15-13 to get up to 27-28 km/h. I do not use the cog 11 often, even with the 40T chainring. So my concern is that even 46T is too much. That's another reason why I haven't changed to the 46T yet.
Riding in the flat area (I think this is yours) you might do alright with more than 44T even on a Vado 4.0. Things change when you get into hilly landscape, during a holiday elsewhere possibly.
So I'm coming from a practical point of view but your calculation sheets add something to consider as well.
And it doesn't require quite a spinning in the cogs 17-15-13 to get up to 27-28 km/h. I do not use the cog 11 often, even with the 40T chainring. So my concern is that even 46T is too much. That's another reason why I haven't changed to the 46T yet.
Riding in the flat area (I think this is yours) you might do alright with more than 44T even on a Vado 4.0. Things change when you get into hilly landscape, during a holiday elsewhere possibly.
So I'm coming from a practical point of view but your calculation sheets add something to consider as well.