it depends on the roads, and the desired tire characteristics for sure. i'll just say this - in over 15,000 miles of road riding on the same set of roads in and around san francisco, by far the most frustrating period was the 1,000 miles or so that i rode on the aethos with tubes. many flats. many rides ruined. yes, i can change a tube, but in no way did i enjoy getting delayed when i needed to be somewhere, a quick 45 minute ride turning into 30 minutes on the bike and 15 minutes of screwing around on the side of the road, the stress of not being sure if i'd be able to get a flat fixed halfway out on a century, or rides completely ruined by multiple flats due to some nearly microscopic piece of glass left in the carcass. tubeless is better in every way for me, less (essentially no) stuff to carry, and literally zero ride ending flats in those other 14,000 miles. i had a small puncture at the top of a 1,000+ meter descent, and i didn't even stop. a little sealant spewed out and i could tell the tire held, so i just bombed it. hit it with a tiny bit of CO2 at the bottom, rode another 20 miles. i splattered some sealant the first two or three times i set it up, piece of cake now.
the only similarly trouble free tubed setup i've ridden on the road were gatorskin hardshells on my creo for 500 miles or so, and yeah, no flats. but tires like that are why people think bicycles need suspensions