Some great advice here, as usual. There are no set-in-stone answers to what you seek; just the solid, real-world experience by each and every one of us who have taken the time to post.
Myself, I can say I've pretty much done it all. Started with Mr Tuffy liners on my Haibike Full FatSix's 4.0 Jumbo Jims on 80mm rims. Got flats on that. I await for the day when Mr Tuffy or somebody does a woven stainless steel mesh and kevlar liner and I'll be the first in line to buy it.......
After the Mr Tuffy's, it was onto tubeless, using Orange Seal sub zero sealant and for any pesky road side punctures, the very nice and expensive DynaPlug Pill Kit along with extra plugs.....https://shop.dynaplug.com/products/dynaplug%C2%AE-pill I thought I was all good until one day road riding in Beverly, NJ and I ran over a piece of steel that tore a good sized hole in the tire. Only through a miracle and about 6 dynaplugs in that hole, did I make it the 12 more miles to homebase. After that, I went back to tubes......but with the added promise of security that Tannus Armour promised.
And a few months into riding, again on the shoulder of an asphalt road, I picked up a quarter inch thorn, that managed to puncture that Tannus Fat Liner, holing the tube in the process. Note to poster @ m@Robertson, one time I did try my standard fat bike tube in the Tannus, but there was no way it would fit on my 80mm rim. I suspect you are using a wider fat bike rim than my 80's?
Today, I still run standard tubes with the TA's and have resigned myself to the facts of life that says no matter which way you go, fats are just part of the game we call ebiking. I do recommend carrying 2 tubes, a patch kit, a good air pump (I use a Lezyne MicroDrive XL
https://ride.lezyne.com/products/1-mp-mfdr-xl-v104 And of course, a pannier to hold all this stuff!
Tannus Armour installation, 7/2020. That pink foam liner has to go into that Schwalbe Jumbo Jim 26x4.0. Tannus provides a smaller sized tube that goes into this liner. I tried fitting my 26x4.0-4.8 tube into the liner and tire, but it would not fit.