If you are saddled with non-removable presta cores, this method works great. Its what I used to do. The hole you make is very small and the sealant you just injected seals the hole if you want to let it. I always patched. But soon after starting to used an in-tube sealant, I made a removable valve core a requirement when buying new tubes.
I had been using Tuffy for years when I went to fat tires on my first ebike. I went to Slime and had to abandon Tuffy because Tuffy's XL construction is thinner to reduce weight, and it literally never met a nail it didn't want to let thru. Slime, on the other hand... if you got a nail or a steel shard or whatever you could hear the problem, jump off the bike, pull the offending bit out and quickly rotate the wheel so the slime could plug it. Part and parcel with this is a pump or co2 to let you refill the tire if the leak takes a while to seal during your ride.
Slime is supposed to be good for holes up to 1/4" and I have taken it right up to that limit. thats about enough to ruin a tire too and the one time I had it happen it took two or three refills to get the slime to hold, but it held. This was back when I was using a Lezyne fat hand pump and co2. Nowadays I use a portable electric pump I plug into my battery.
And speaking of Slime and 1/4"... that formula has remained unchanged pretty muc forever. A competitor is FlatOut and their Sportsman formula was tested on fat ebikes. You use a lot of it (16 oz on a 4.0" tire) but it *never dries out* and an application lasts the life of the tire. Flatout is advertised as good for a 1/2" hole, and on one fat bike hole (twisted piece of steel) that made a 1/4" plus hole, it sealed the tube. Later inspection showed the tube had sealed dry with a tough little plug, unlike slime plugged holes which usually weep forever. My only other flat was when I used FlatOut as a tubeless sealant (!) and it plugged a 6-hole line of nails when I somehow managed to hit a strip of roofing nails left from someone's nail gun.
As a tubeless sealant it is incredible. Better than the Stan's or Orange Seal Endurance I have also used, because it can plug the big holes rather than just the goatheads. And it never dries out, so no Stans boogers or Orange Seal film dried to the inside surface of the tire.