A 52V pack is 14 series groups. Let's say the lowest safe voltage is 3V/cell. that gives you 3 x 14 = 42V.
There are two low voltage cutoffs to consider. One in bike controller and one in battery, Ebike controllers usually set a higher LVC than what a battery BMS will set. Many 48V controllers will run on 52V packs, but their internal low voltage cutoffs remain set for a 48V pack, around 40V.
That's a little too low for a 52V pack. If you can adjust the controller LVC via settings, it's a good idea to do so. I set mine to 43V. Can't go any higher or I would. There's not much left in a 52V pack when it gets down to 45V.