You can use a powerful rear hub motor and use torque arms to spread out the torque load on the rear dropouts, so you don't necessarily have to go the mid-drive route.
I would strongly recommend adding a front suspension if your ebike build is going to have more than 350W or attain speeds of 22mph+ on flat ground, however, some road bikes don't have the right geometry for adding a front suspension (you could do it, but it's just not optimal). Also, you'd want to run at least 32c (if not 45c) tires, and that might require changing out your wheels, too, as some road bike wheelsets are better fits for thinner (23c-25c) tires.
I'm looking at turning a touring/road bike with CF fork and disc brakes into an ebike soon, and I'll be facing the same issues (adding suspension, attaching torque arms, using bigger tires, etc). Luckily, the bike I'm looking to convert allows for big/wide tires (38c, I believe), which is wide enough for a 45lb ebike + 180lb rider.