I am. In my experience the wheel is the most important part along with maybe the suspension fork.
I started bike commuting in 2000 at 400lbs and lost 170lbs in about a year and a half on an entry level Trek mountain bike that definitely wasn’t rated for my weight. I then spent the next 8 years riding a Trek 1000 road bike. Once again a hand-built wheel did the trick, even though I was never below 250 (I’m legitimately just a big guy that will never be that light, even when I’m eating perfect and cycling 35 miles a day) - the bike was great for me.
Unfortunately I was hit by a car a little over 10 years ago and that messed me up for quite a while. When I could finally get back on the bike regularly and not worry about getting hit, I’d gained some weight and started riding eBikes. Same drill. A well-built wheel and I don’t really have trouble. I didn’t have any trouble on my Trek Verve+ 3 (which I think has 2 piston brakes) and I don’t anticipate having trouble on the Vado once I get a wheel built.
I was just surprised by how insistent the salesperson was about the 4 piston brakes. My other bike is a Brompton with rim brakes. Maybe not advisable, but it can be done. And it’s not like I’m off-roading. I’m just running errands and getting around town.
All that said, since I’m starting fresh this time (I just sold my Tern) I may take this opportunity to spring for the lost stable and best braking Vado model I can (5.0, standard frame, non-SL), just to hedge my bets.
I’ve looked at the Riese and Mueller bikes, but it’s not clear to me what the geometry on the bikes is and I am trying to find a specific fit that the Vado meets.