The Schwalbe Marathon Plus tires will be difficult to deal with if you don't remove the wheel from the bike. I just put a set of the same tires on my Trek non-ebike last weekend and I can't imagine trying to pop one side off in order to patch the tube and then pop it back on without being able to manhandle it off the bike. If you didn't install the Schwalbes yourself, review the steps in this
YT video to become familiar with the process to make it easy. I also recommend the
Schwalbe tire levers, and make sure you have cable ties and something to cut the ties off when you're done.