On a recent long ride, part of it was on US 50 in NV, which has wide shoulders (it is a designated bike route in this state). The other part was on Alt 95, which had almost no shoulder, and half of that was a rumble strip. At one point, it was just rumble strip, so I literally road the white line at the edge of the lane. Most vehicles gave me a wide berth. One so-and-so semi came within one foot, which scared me greatly. Needless to say, I'll never ride that highway again.
Interesting thing about US 50 - When you hit Utah, it is no longer a designated bike route, and stays that way across most of the US. I think it is in Ohio where it becomes a bike route again, and remains so into MD and DC. In CA, US 50 is a mixed bag. BTW US 50 runs from Sacramento, CA to Ocean City, MD. Parts of it are the old Lincoln Highway.
If you are going to ride US 50 in NV, they don't call it "The loneliest highway in America" for no reason. There are some long stretches of nothing, especially towards the Eastern part of the state. I hosted a cyclist recently, who was touring the country, and he indicated that Utah wasn't any better.