A very open ended question. Compare on what basis?
If I want to be positive, the 380 will have a lot more range left because if you use the battery to go over 20mph, much of that energy will be lost to aero drag. The power used goes up with the cube of the speed, so it takes 2.7 times as much power to do 28mph than it does to do 20mph. But if you are 5 miles from home facing a 25mph headwind, you won't care about that as long as the battery will get you home. These Class 3 bikes really need an easily available second battery.
If you want the option, then get the 380+, and upgrade from a Purion to a Nyon for about $350+labor and use the alternate modes to shut electric assist off at 20mph. Or don't pedal faster than that except in off mode.