I am a big guy, and I ride my 4" tires at 20 front/25 rear with my regular commuter cargo. I might go as high as 23F/28R if I'm loading up a ton of cargo, but you quickly lose the cushy benefit of fat tires up there. Normally, 15-20 all around is a nice mix of cushy and decent rolling resistance, but you should try it out with a few psi either way and see what you like based on your riding style and weight.
The biggest consideration is avoiding pinch flats. if you are a lazy cruiser, softer tires down to 15 can completely eliminate vibration or the feel of sidewalk cracks, etc. And slightly lower pressures can increase the tires footprint and loose/soft/wet surface traction. Off-roaders and winter/snow and sand riders can sometimes go below 10psi on 4.8-5" tires to really maximize grip. If you are somewhat aggressive and like to play a little, e.g. jump on/off high curbs, or ride very fast on rough trails, a little more pressure will protect your tubes and stiffen up the rim and spokes to reduce broken or bent parts. But too much pressure can actually increase tire damage on sharp rocks as the tire can't deform around it, and the impact point becomes small and sharp.
I don't see too many situations outside of the heaviest cargo bikes where a recreation rider would need max PSI in a 4" or larger tire, and good quality tires still achieve ideal rolling resistance well below the max pressure. I don't find any improvement in range above 25psi, and barely notice it above 20, but I do notice the ride starts to get harsh quickly.
Last caveat, is that some specialty "Street" fat tires self-steer badly at lower pressures, and running higher pressure reduces or eliminates that problem.