Honestly i donot know. I have at present a stock GX drivetrain - RD SRAM GX, long cage, 11-speed, SRAM PG-1130, 11-speed, 11-42t cassette, Praxis, 48T, 104BCD front chainring. As far i can tell and i am not an expert the SRAM AXS is a 12 speed drivetrain wherefore too big for my Vado 5.0 but...